September 5, 2007Circulation
Change in Salt Intake Affects Blood Pressure of Chimpanzees
Why the study?
Does lowering sodium intake reduce blood pressure in chimpanzees?
Population
127 chimpanzees (17 in Franceville, Gabon, and 110 in Bastrop, Texas)
Comparison
Lowered sodium intake vs Standard diet of 250 mmol/d sodium or different…
Design
Preclinical
Follow-up
2 to 3 years
Authors
Discussion
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Implication
Supports sodium-BP link in chimpanzees; hypothesis-generating for human dietary guidelines.
Structured PICO
Does lowering sodium intake reduce blood pressure in chimpanzees?
P
Population
127 chimpanzees (17 in Franceville, Gabon, and 110 in Bastrop, Texas)
I
Intervention
Lowered sodium intake (Gabon: episodic changes from 75 to 35 to 120 mmol/d over 3 years; Bastrop: halved from 250 mmol/d for 2 years)
C
Comparator
Standard diet of 250 mmol/d sodium (in Bastrop) or different sodium levels (in Gabon)
O
Outcome
Systolic, diastolic, and mean arterial blood pressuressurrogate
Modest reductions in sodium intake significantly lower blood pressure in chimpanzees, providing strong evolutionary support for human dietary sodium reduction.
Cite This Study
Elliott et al. (2007) studied this question.