December 16, 2003Journal of Hypertension

Cathepsin G is associated with atheroma formation in human carotid artery

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Population

21 hypertensive patients undergoing carotid endarterectomy

Design

Cross-sectional

Authors

LLLiliana LegedzUniversité Claude Bernard Lyon 1 JRJacques RandonUniversité Claude Bernard Lyon 1 CSCarmine SessaUniversité Joseph Fourier

Discussion

Member takes

Implication

No immediate clinical implications; leaves open whether cathepsin G or ACE drives local Ang II production in plaques.

Structured PICO

Population

21 hypertensive patients undergoing carotid endarterectomy (tissue samples analyzed: atheroma plaque, fatty streaks, and macroscopically intact tissue)

Comparator

Macroscopically intact tissue and fatty streaks (within-patient comparison)

Outcome

Expression (mRNA levels) and cellular localization of angiotensin system components (renin, angiotensinogen, ACE, AT1, AT2) and cathepsins D and Gsurrogate

Cathepsin G and ACE are overexpressed in human carotid atheroma, suggesting they may drive local angiotensin II production independently of renin in the arterial wall.

Cite This Study

Legedz et al. (2003) studied this question.

synapsesocial.com/papers/69f29d891b51e2fbf018764a https://doi.org/10.1097/00004872-200401000-00025

View Full Paper

Ask AI

Bookmark

Cathepsin G is associated with atheroma formation in human carotid artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cathepsin G is associated with atheroma formation in human carotid artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider