Key result
A low sodium diet (0.02%) for 5 days increased angiotensinogen mRNA levels in the aortic medial smooth muscle of WKY rats by 3.2-fold (P < 0.005) compared to a 1.6% sodium diet, without affecting levels in periaortic fat.
Why the study?
Does dietary sodium regulate angiotensinogen mRNA expression in the blood vessel wall of rats?
Population
Wistar and Wistar Kyoto (WKY) rats
Comparison
Low sodium diet (0.02% sodium) for 5 days vs 1.6% sodium diet
Design
Preclinical
Follow-up
5 days
Authors
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No immediate clinical implications; extends evidence for local vascular RAS in rodent models.
Does dietary sodium regulate angiotensinogen mRNA expression in the blood vessel wall of rats?
Effect estimate: 3.2-fold increase
Absolute Event Rate: 3.2% vs 1%
p-value: p=<0.005
Dietary sodium differentially regulates angiotensinogen mRNA expression in the vascular smooth muscle versus periaortic fat in rats.
Naftilan et al. (1991) studied Healthy rats (n=36). Low sodium diet vs. Normal sodium diet (1.6%) was evaluated on Angiotensinogen mRNA levels in aortic medial smooth muscle (3.2-fold increase, p=<0.005). A low sodium diet (0.02%) for 5 days increased angiotensinogen mRNA levels in the aortic medial smooth muscle of WKY rats by 3.2-fold (P < 0.005) compared to a 1.6% sodium diet, without affecting levels in periaortic fat.
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