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December 1, 1996Circulation

Increased Accumulation of Tissue ACE in Human Atherosclerotic Coronary Artery Disease

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Population

Human nonatherosclerotic and atherosclerotic coronary arteries, and a monocytoid cell line

Comparison

Immunohistochemical analysis of ACE expression… vs Nonatherosclerotic versus atherosclerotic…

Design

Preclinical

Authors

FDFrank DietUniversity of Cologne RPRichard E. PrattHeart Failure & Transplant GBGerald J. BerryHeart Failure & Transplant

Discussion

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Implication

Local ACE in inflammatory plaques identifies a potential CAD target; hypothesis-generating and requires clinical validation before practice change.

Key Points

The aim is to investigate the role of tissue ACE in human coronary artery disease and its mechanisms.
Immunohistochemical examination of ACE expression in coronary arteries.
Comparison of ACE localization in nonatherosclerotic and atherosclerotic tissues.
In vitro studies using monocytoid cell lines to evaluate ACE activity.
ACE immunoreactivity found primarily in macrophage regions in early atherosclerotic lesions.
ACE activity increased threefold in macrophages after differentiation and further increased with acetylated LDL stimulation.
Local angiotensin production linked to ACE accumulation suggests a role in the pathobiology of coronary artery disease.

Structured PICO

P

Population

Human nonatherosclerotic and atherosclerotic coronary arteries, and a monocytoid cell line

I

Intervention

Immunohistochemical analysis of ACE expression and in vitro macrophage differentiation/stimulation with acetylated LDL

C

Comparator

Nonatherosclerotic versus atherosclerotic arteries; undifferentiated versus differentiated macrophages; unstimulated versus acetylated LDL-stimulated macrophages

O

Outcome

Localization and expression levels of tissue ACE and angiotensin IIsurrogate

Tissue ACE accumulates in inflammatory regions of human atherosclerotic plaques, suggesting a local mechanism for angiotensin production and a target for ACE inhibitors in coronary artery disease.

Cite This Study

Diet et al. (1996) studied this question.

synapsesocial.com/papers/6a10113f2badbc352aff4200 https://doi.org/10.1161/01.cir.94.11.2756

Topics

Coronary artery disease Coronary CT angiography

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Presence of angiotensin converting enzyme in the adventitia of large blood vessels1992 · 55 citations
2Potential importance of tissue angiotensin-converting enzyme inhibition in preventing neointima formation.1994 · 137 citations
3Inhibitors of Angiotensin-Converting Enzyme Prevent Myointimal Proliferation After Vascular Injury1989 · 1,060 citations
4Feedback regulation of angiotensin converting enzyme activity and mRNA levels by angiotensin II.1993 · 159 citations
5Monocyte heterogeneity in angiotensin-converting enzyme induction mediated by autologous T lymphocytes1992 · 7 citations