Key result
Enhanced ACE expression was strongly associated with macrophages and smooth muscle cells in hypercellular lesions, atheromatous plaques, and ruptured plaques in human coronary arteries.
Population
44 coronary artery segments from 19 corpses, including patients who died from acute myocardial infarction
Design
Cross-sectional
Authors
Loading...
Supports ACE inhibitor vasculoprotection in CAD; hypothesis-generating for lesion-targeted therapies.
Observational (n=19)
Enhanced ACE expression in active atherosclerotic and ruptured plaques provides a mechanistic rationale for the vasculoprotective effects of ACE inhibitors in coronary artery disease.
Ohishi et al. (1997) conducted an observational in Coronary atherosclerosis (n=19). Enhanced ACE expression vs. Normal arteries or fibrosclerotic plaques was evaluated on ACE expression in different histologic types of coronary artery segments. Enhanced ACE expression was strongly associated with macrophages and smooth muscle cells in hypercellular lesions, atheromatous plaques, and ruptured plaques in human coronary arteries.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: