Key result
Angiotensin II, AT1 receptor, and ACE colocalize with IL-6 in human coronary atherosclerotic plaques, and Ang II induces IL-6 synthesis, suggesting RAS contributes to vascular inflammation.
Population
Human coronary arteries from patients with ischemic or dilated cardiomyopathy undergoing heart…
Design
Preclinical
Authors
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May implicate local RAS in coronary plaque inflammation; hypothesis-generating and requires clinical validation.
Observational (n=33)
The local production of Angiotensin II within coronary plaques and its induction of IL-6 suggests the renin-angiotensin system directly contributes to vascular inflammation and acute coronary syndromes.
Schieffer et al. (2000) conducted an observational in Coronary artery disease (n=33). Immunohistochemical analysis and in vitro Ang II stimulation was evaluated on Colocalization of Ang II, ACE, AT1 receptor, and IL-6 in coronary arteries and IL-6 synthesis after Ang II stimulation. Angiotensin II, AT1 receptor, and ACE colocalize with IL-6 in human coronary atherosclerotic plaques, and Ang II induces IL-6 synthesis, suggesting RAS contributes to vascular inflammation.
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