Key result
Preoperative treatment with ramipril or valsartan markedly decreased the expression of inflammatory cytokine genes in coronary microvessels of patients with unstable angina.
Why the study?
Does short-term preoperative treatment with ramipril or valsartan reduce coronary microvessel inflammation in patients with unstable angina?
Population
64 patients undergoing cardiac surgery, including 43 with 2-vessel disease unstable angina undergoing…
Comparison
Ramipril or valsartan administered during the 5… vs Placebo administered during the 5 days preceding…
Design
RCT, randomly assigned
Follow-up
5 days
Authors
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Supports preoperative ACEI/ARB to attenuate coronary microvessel inflammation in unstable angina; extends evidence for local Ang II in immunomediated vascular inflammation.
RCT (n=64)
randomly assigned
Does short-term preoperative treatment with ramipril or valsartan reduce coronary microvessel inflammation in patients with unstable angina?
Short-term preoperative treatment with ramipril or valsartan reduces the expression of inflammatory cytokines in the coronary microvessels of patients with unstable angina, highlighting the role of locally generated Angiotensin II in immunomediated inflammation.
Serneri et al. (2004) conducted an RCT in Unstable angina (n=64). Ramipril or valsartan vs. Placebo was evaluated on Expression levels of TNF-alpha, IL-6, iNOS, and IFN-gamma genes. Preoperative treatment with ramipril or valsartan markedly decreased the expression of inflammatory cytokine genes in coronary microvessels of patients with unstable angina.
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