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This research investigates the role of Zizhu Ointment in healing diabetic foot ulcers by targeting mast cell activity.

April 30, 2026Journal of Diabetes Research0 citationsOpen Access

Zizhu Ointment Inhibits IgE–FcεRI Signaling‐Mediated Mast Cell Degranulation to Promote the Healing of Diabetic Foot Ulcers

JSJian SunShanghai University of Traditional Chinese Medicine XZX F ZhangShanghai University of Traditional Chinese Medicine MYMeijie YuanShanghai University of Traditional Chinese Medicine

Key Points

This research investigates the role of Zizhu Ointment in healing diabetic foot ulcers by targeting mast cell activity.
Examined the effects of Zizhu Ointment on mast cell degranulation.
Analyzed the release of inflammatory mediators, including histamine.
Investigated FcεRI-proximal signaling pathways and inflammatory cascades.
Zizhu Ointment reduced the release of histamine in mast cells.
It inhibited inflammatory mediators linked to diabetic foot ulcers.
Healing was promoted through stabilization of mast cells.

Abstract

) influx, and the release of β-hexosaminidase, histamine (HIS), and TNF-α in both human HMC-1 and murine P815 mast cells. Furthermore, ZZO was found to block the IgE/DNP cross-linking-mediated activation of FcεRI-proximal signaling pathways (LYN/SYK/PLCγ) and inflammatory cascades (IKK/NFκB and MAPKs). We hypothesize that ZZO facilitates the healing of diabetic ulcers by stabilizing mast cells and inhibiting their degranulation, thereby reducing the release of inflammatory mediators and promoting wound repair.

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