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April 30, 2026Open Access

TGF-beta inhibitors in cancer therapy: a review of the TGF-beta signal transduction pathway and current developments

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Authors

STShun-Ban TaiJYJenq‐Lin YangNational Sun Yat-sen UniversityPLPei‐Feng LiuNational Sun Yat-sen University

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Implication

Review highlights therapeutic targeting of TGF-beta signaling in cancer, showing its dual role in tumor suppression and promotion of disease.

Key Points

  • To explore therapeutic strategies targeting TGF-beta signaling in cancer therapy.
  • Review of current developments in TGF-beta signal transduction mechanisms
  • Analysis of therapeutic approaches such as ligand neutralization and receptor kinase inhibition
  • Emphasis on regulatory mechanisms modulated by existing drugs and clinical candidates
  • Identified TGF-beta's dual role as tumor suppressor and promoter in cancer progression
  • Discussed challenges in targeting TGF-beta signaling due to its regulatory complexity
  • Proposed drug repurposing and combination strategies to enhance therapeutic efficacy

Cite This Study

Tai et al. (2026) studied this question.

synapsesocial.com/papers/69f2a4578c0f03fd677634achttps://doi.org/10.17179/excli2026-9381
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