Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 13, 2025Acta Biochimica Iranica

A Mini Review on the Multifaceted Role of TGF-β in Metastasis Progression: Molecular Mechanisms and Novel Therapeutic Strategie

View Full Paper
Ask AI
Bookmark
Share

Authors

YMYaser MohammadiMNMitra Nourbakhsh

Discussion

Loading...

Member takes

Overview

Mini review highlights the dual role of TGF-β in tumor progression and metastasis, suggesting novel therapeutic pathways.

Key Points

  • TGF-β acts as both a tumor suppressor and a promoter of metastasis in different cancer stages.
  • It regulates cellular functions through SMAD and non-SMAD pathways, affecting tumor invasiveness and chemotherapy resistance.
  • Targeted therapies against TGF-β show promise, but challenges like tumor resistance complicate treatment.
  • Refining TGF-β therapies and combining them with immunotherapy may enhance therapeutic effectiveness.

Cite This Study

Mohammadi et al. (2025) studied this question.

synapsesocial.com/papers/689a02afe6551bb0af8cbfc7https://doi.org/10.18502/abi.v2i3.19096
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1TGF-beta inhibitors in cancer therapy: a review of the TGF-beta signal transduction pathway and current developments2026
  2. 2TGF-β Signaling in Cancer: Mechanisms of Progression and Therapeutic Targets2025 · 41 citations
  3. 3TGF‑β1 in cancer: From tumour suppressor to promoter, molecular mechanisms, and precision therapeutic strategies (Review)2026
  4. 4Recent advances in therapeutic use of transforming growth factor-beta inhibitors in cancer and fibrosis2025 · 15 citations
  5. 5The Dual Role of Transforming Growth Factor-Beta (TGF-β) Signaling: Balancing Cellular Senescence and Tumor Progression for Precision Therapeutics.2025