Fluoxetine treatment improves gene expression in myocardialß-adrenergic receptors, suggesting benefits for stress-induced depression in rats.
Changes in gene expression of ß1- and ß2-adrenoceptors (ß1- and ß2-AR) in right and left atria and ventricles after fluoxetine treatment in stress-induced depression of adult rat males were studied. Elevated ß1-AR mRNA levels in the left atria and significantly higher levels of ß2-AR mRNA in the left atria and ventricles were observed in stress-induced depression in comparison with those of unstressed controls. Fluoxetine treatment led to increasing expression of ß1-AR mRNA in the right atria and left ventricles, while the level of ß2-AR mRNA remained unchanged. These findings suggest that fluoxetine therapy plays an important role in cardiac ß-adrenergic subsensitivity and gene regulation of ß-AR in animals with heightened sympathetic nervous activity.
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Spasojevic et al. (2011) studied this question.
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