What question did this study set out to answer?

To identify characteristics associated with non-progression to RA in anti-CCP positive individuals with new symptoms.

OA40 Predicting good long-term prognosis in anti-CCP positive individuals with new musculoskeletal symptoms: 10-year data from a national prospective research cohort

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To identify characteristics associated with non-progression to RA in anti-CCP positive individuals with new symptoms.
Prospective observational cohort study involving CCP+ individuals from the Leeds CCP study.
Data collected on demographic, clinical, serological, and ultrasound characteristics.
Univariate and multivariate logistic regression analyses performed to identify prognostic factors.
After 5 years, 317 out of 450 did not progress to RA; after 10 years, 73 out of 157 remained arthritis-free.
Factors associated with non-progression included low anti-CCP levels and normal ESR at baseline.
No individuals with all good prognosis characteristics progressed to RA at either time point.

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Observational cohort study shows good prognostic factors for arthritis-free status in CCP+ individuals, highlighting management strategies.

Sharrack et al. (2026) studied this question.

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Observational cohort study shows good prognostic factors for arthritis-free status in CCP+ individuals, highlighting management strategies.