What question did this study set out to answer?

To identify immune and signaling elements involved in systemic sclerosis at its early stages.

P121 Spatial transcriptomics reveals cellular and mitochondrial stress-driven immune signatures that trigger stromal remodeling the subepidermal perivascular region of skin biopsies from very early diagnosis of systemic sclerosis patients

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To identify immune and signaling elements involved in systemic sclerosis at its early stages.
Employed digital spatial transcriptomics to analyze skin biopsies from patients with early systemic sclerosis and healthy controls.
Mapped transcriptome expression in the subepidermal region surrounding CD34-stained vessels.
Analyzed differentially expressed genes to explore related biological pathways.
Identified significant cellular stress and immune reprogramming in systemic sclerosis skins.
Notable immune populations included macrophages and lymphatic endothelial cells indicating inflammation.
Upregulation of pathways related to hypoxia and mitochondrial dysfunction linked to early disease processes.

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Spatial transcriptomics demonstrates cellular stress and immune signatures in systemic sclerosis, suggesting potential for early detection.

Bamigbola et al. (2026) studied this question.

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Spatial transcriptomics demonstrates cellular stress and immune signatures in systemic sclerosis, suggesting potential for early detection.