Why the study?
The pathogenesis of chronic aortic regurgitation differs between males and females.
Are there sex differences in aortic valve inflammation and remodeling in patients with chronic severe aortic regurgitation?
Are there sex differences in aortic valve inflammation and remodeling in patients with chronic severe aortic regurgitation?
There are distinct sex-specific molecular pathways in chronic severe aortic regurgitation, with females exhibiting less inflammation and collagen accumulation but more proteoglycan secretion than males.
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Should not yet change AR practice; hypothesis-generating for sex-specific remodeling in animal models.
The pathogenesis of chronic aortic regurgitation (AR) is different in male and female. Female patients with AR showed less aortic valve inflammation and collagen accumulation as compared with male. Valvular cells from female patients secreted less inflammatory molecules and collagen and higher levels of proteoglycans. Valvular interstitial cells from females were more sensitive to transforming growth factor (TGF)-β-induced proteoglycans secretion. Our study opens a new perspective oriented toward sex-specific molecular pathways and therapeutic targets in chronic severe AR.
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Tiraplegui et al. (2025) studied this question.
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