April 17, 2015JACC. Cardiovascular imagingOpen Access

Cardiac Mechanical Alterations and Genotype Specific Differences in Subjects With Long QT Syndrome

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Population

192 subjects with genotyped long QT syndrome (139 LQT1, 53 LQT2)

Design

Cross-sectional

Authors

ILIda S. LerenElectrophysiology NHNina E. HasselbergHeart Failure & Transplant JSJørg SaberniakElectrophysiology

Discussion

Member takes

Implication

Subclinical mechanical dysfunction detectable in LQTS by strain imaging; leaves open its prognostic value and role in risk stratification.

Structured PICO

Population

192 subjects with genotyped long QT syndrome (139 LQT1, 53 LQT2)

Comparator

60 healthy persons of similar age and sex

Outcome

Systolic function (left ventricular ejection fraction, global longitudinal strain, contraction duration, mechanical dispersion) and diastolic function (transmitral filling velocities, early diastolic myocardial velocity, left atrial volume index) assessed by echocardiographysurrogate

Long QT syndrome is associated with measurable reductions in both systolic and diastolic mechanical function, with worse global longitudinal strain in LQT2 compared to LQT1.

Cite This Study

Leren et al. (2015) studied this question.

synapsesocial.com/papers/69f2cb67be8e9f1f31c57915 https://doi.org/10.1016/j.jcmg.2014.12.023

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Implication

Subclinical mechanical dysfunction detectable in LQTS by strain imaging; leaves open its prognostic value and role in risk stratification.

Cardiac Mechanical Alterations and Genotype Specific Differences in Subjects With Long QT Syndrome

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiac Mechanical Alterations and Genotype Specific Differences in Subjects With Long QT Syndrome

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider