Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro–aged or –injured mouse platelets
Why the study?
Does metalloproteinase inhibition improve the recovery and hemostatic function of in vitro-aged or injured mouse platelets?
Population
In vitro-aged or mitochondria-injured (via CCCP) mouse platelets
Comparison
Metalloproteinase inhibitors vs No metalloproteinase inhibition
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Metalloproteinase inhibition may enhance recovery of stored platelets in mice; leaves open translation to human transfusion practice.
Structured PICO
Does metalloproteinase inhibition improve the recovery and hemostatic function of in vitro-aged or injured mouse platelets?
P
Population
In vitro-aged or mitochondria-injured (via CCCP) mouse platelets
I
Intervention
Metalloproteinase inhibitors
C
Comparator
No metalloproteinase inhibition
O
Outcome
Posttransfusion recovery and hemostatic function in vivosurrogate
Inhibition of metalloproteinase activity during platelet storage could significantly improve the effectiveness of platelet transfusions by preventing GPIbalpha proteolysis.
Cite This Study
Bergmeier et al. (2003) studied this question.