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April 30, 2026Aerospace Medicine and Human Performance

Space Radiation Effects on the Glutathione Redox Cycle and Cataract Formation

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Authors

BKBlake Douglas KatsevRLRyung LeeJKJi Hyun Kim

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Overview

Review explores how space radiation affects cataract formation via oxidative stress and glutathione depletion in astronauts.

Key Points

  • This review examines the relationship between space radiation exposure and cataract formation, focusing on oxidative stress and glutathione depletion.
  • Systematic review of literature from multiple databases including PubMed and NASA sources on cataracts and radiation.
  • Total of 3308 articles identified and filtered to 392 for analysis.
  • Ionizing radiation induces oxidative stress, increasing free radicals and depleting glutathione, a critical antioxidant.
  • Compromised glutathione levels lead to protein aggregation and lens opacification, causing cataracts.
  • Proposed countermeasures include optimizing antioxidant defenses and implementing protection strategies like radiation shielding.

Cite This Study

Katsev et al. (2026) studied this question.

synapsesocial.com/papers/69f2f1471e5f7920c6387062https://doi.org/10.3357/amhp.6809.2026
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