Retroperitoneal Liposarcoma: A Case Report and Review of Management Strategies

Retroperitoneal liposarcoma is an uncommon malignant soft-tissue neoplasm that often presents late due to the expansile nature of the retroperitoneal space. Here, we report the case of a 74-year-old male who presented with a rapidly enlarging abdominal mass. Cross-sectional imaging demonstrated a large, fat-attenuating retroperitoneal lesion with internal septations and calcific foci, raising suspicion for a well-differentiated liposarcoma. Complete surgical excision was achieved, and histopathological examination confirmed an atypical lipomatous tumor/well-differentiated liposarcoma with clear resection margins. This case report emphasizes the importance of early recognition, accurate radiological characterization, and meticulous surgical resection, which together remain the cornerstone of management.