What question did this study set out to answer?

This study aims to evaluate the impact of methotrexate on liver health, particularly assessing liver toxicity in patients with inflammatory rheumatism.

April 30, 2026Lara D. Veeken

P118 Assessment of methotrexate-induced liver toxicity in patients with inflammatory rheumatic diseases: an observational study based on FIB-4 and FibroScan

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Authors

MMManal MaghfourCentre Hospitalier Universitaire Ibn Rochd LSLamiaa SettaCentre Hospitalier Universitaire Ibn Rochd KNKhaireh Amoud NasserCentre Hospitalier Universitaire Ibn Rochd

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Implication

Observational study evaluates liver toxicity indicators in patients with inflammatory rheumatism, suggesting improved monitoring strategies.

Key Points

This study aims to evaluate the impact of methotrexate on liver health, particularly assessing liver toxicity in patients with inflammatory rheumatism.
Retrospective study conducted from January 2021 to March 2025
Included patients treated with methotrexate for inflammatory rheumatism experiencing hepatic side effects
Utilized FIB-4 scores and FibroScan to assess liver function and fibrosis
Thirty patients were included after reviewing 680 cases, with a mean age of 53.4 years and predominance of women (93.3%)
No significant association found between liver fibrosis and cumulative methotrexate dose (p=0.225), duration of exposure (p=0.667), or weekly dose (p=0.412)
The mean FIB-4 fibrosis score was 1.66, indicating low risk of liver damage in absence of steatosis.

Cite This Study

Maghfour et al. (2026) studied this question.

synapsesocial.com/papers/69f2f1be1e5f7920c638767f https://doi.org/10.1093/rheumatology/keag121.152

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Implication

Observational study evaluates liver toxicity indicators in patients with inflammatory rheumatism, suggesting improved monitoring strategies.

P118 Assessment of methotrexate-induced liver toxicity in patients with inflammatory rheumatic diseases: an observational study based on FIB-4 and FibroScan

Discussion

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Implication

Key Points

Cite This Study

P118 Assessment of methotrexate-induced liver toxicity in patients with inflammatory rheumatic diseases: an observational study based on FIB-4 and FibroScan

Discussion

Member takes

Implication

Key Points

Cite This Study

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