Why the study?
Do maternal chronic medical conditions increase the risk of congenital heart defects in offspring?
Population
2,278,838 mother-infant pairs in Canada (excluding Quebec) from 2002 to 2010.
Comparison
Maternal chronic medical conditions and… vs Absence of these maternal conditions.
Design
Cohort
Follow-up
Infancy
Authors
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May guide preconception counseling in high-risk mothers; leaves open whether interventions reduce offspring CHD incidence.
Do maternal chronic medical conditions increase the risk of congenital heart defects in offspring?
Several maternal chronic conditions, notably congenital heart disease and diabetes, are strongly associated with an increased risk of congenital heart defects in offspring.
Liu et al. (2013) studied this question.
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