Body Fat Distribution, Incident Cardiovascular Disease, Cancer, and All-Cause Mortality
Key result
Higher visceral adipose tissue linked to ~44% greater CVD and cancer risk per SD.
- HR 1.44
- 95% CI 1.08 to 1.92
- P=0.01
- n=3,086
Why the study?
Morbidity varies among individuals of similar body mass index, and while ectopic fat depots may explain this risk differential, prospective studies of directly measured fat are limited.
Population
3086 Framingham Heart Study participants
Comparison
Per 1 standard deviation increment in visceral, pericardial, and periaortic adipose tissue
Design
Prospective cohort study
Follow-up
Median of 5.0 years
Authors
Discussion
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Member takes
Implication
Should not yet change practice; leaves open whether reducing visceral adipose tissue prevents CVD and cancer.
Study Design
Type
Cohort (n=3,086)
PICO
P
Population
Incident cardiovascular disease, cancer, and all-cause mortality (n=3,086)
I
Intervention / Comparator
Visceral adipose tissue (per 1 SD increment)
O
Primary Outcome
Incident cardiovascular disease — HR 1.44 (1.08 to 1.92), p=0.01
Main Result
Effect estimate: HR 1.44 (95% CI 1.08 to 1.92)
p-value: p=0.01
Cite This Study
Britton et al. (2013) conducted a cohort in Incident cardiovascular disease, cancer, and all-cause mortality (n=3,086). Visceral adipose tissue (per 1 SD increment) was evaluated on Incident cardiovascular disease (HR 1.44, 95% CI 1.08 to 1.92, p=0.01). Visceral adipose tissue (per 1 SD increment) was associated with incident cardiovascular disease (HR 1.44; 95% CI 1.08-1.92; p=0.01) and cancer (HR 1.43; 95% CI 1.12-1.84; p=0.005).