April 30, 2026Journal of the American College of Cardiology
Right ventricular pacing reduces the rate of left ventricular relaxation and filling
Why the study?
Right ventricular pacing alters left ventricular synchrony and loading conditions, and the study sought to separate the effects of altered loading from those of asynchrony on left ventricular relaxation and filling.
Does right ventricular pacing reduce the rate of left ventricular relaxation and filling in open chest anesthetized dogs?
Population
12 open chest anesthetized dogs
Comparison
Right ventricular pacing and sequential AV pacing vs right atrial pacing
Design
Preclinical animal physiology study
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for RV pacing effects on LV relaxation; prospective trials needed before clinical adoption.
Structured PICO
Does right ventricular pacing reduce the rate of left ventricular relaxation and filling in open chest anesthetized dogs?
P
Population
12 open chest anesthetized dogs
I
Intervention
Right ventricular pacing and sequential AV pacing
C
Comparator
Right atrial pacing
O
Outcome
Rate of isovolumic pressure decline (relaxation time constant), myocardial (segment) lengthening rate and chamber (minor axis dimension) filling ratesurrogate
Right ventricular pacing impairs left ventricular relaxation and filling rates in a canine model, demonstrating the adverse mechanical effects of ventricular asynchrony.
Cite This Study
Zile et al. (1987) studied this question.