Why the study?
Patients with heart failure have a poor prognosis and are categorized by ejection fraction, but differences in outcomes across HFpEF, HFbEF, and HFrEF required characterization.
Does 5-year mortality differ among patients hospitalized with heart failure based on ejection fraction category (HFrEF, HFbEF, HFpEF)?
Population
39,982 patients admitted for HF from 254 hospitals
Comparison
HFpEF (EF ≥50%) vs HFbEF (EF 41% to 49%) vs HFrEF (EF ≤40%)
Design
Registry-based longitudinal cohort study linked to Medicare data
Follow-up
5 years
Authors
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Caution warranted against LVEF-based prognostic assumptions in HF; leaves open prospective trials of phenotype-specific therapies.
Does 5-year mortality differ among patients hospitalized with heart failure based on ejection fraction category (HFrEF, HFbEF, HFpEF)?
Patients hospitalized with heart failure have a similarly poor 5-year survival across the entire ejection fraction spectrum, which is markedly lower than the general U.S. population.
Shah et al. (2017) studied this question.
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