Why the study?
Sex-based differences in the association of lipoprotein(a) with cardiovascular outcomes have not been well established for individuals without prior atherosclerotic cardiovascular disease.
Is elevated lipoprotein(a) associated with cardiovascular outcomes in men and women without prior atherosclerotic cardiovascular disease?
Is elevated lipoprotein(a) associated with cardiovascular outcomes in men and women without prior atherosclerotic cardiovascular disease?
Elevated lipoprotein(a) is a significant risk factor for myocardial infarction in both men and women without prior ASCVD, though women under 60 have a lower risk than men.
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Extends Lp(a)-MI link to primary prevention without prior ASCVD; leaves open whether lowering Lp(a) reduces events.
BACKGROUND: Sex-based differences in the association of lipoprotein(a) with cardiovascular outcomes have not been well established for those without prior atherosclerotic cardiovascular disease. METHODS AND When examining individual outcomes, the strongest association was present between lipoprotein(a) and fatal or nonfatal myocardial infarction (women: adjusted HR, 2.61 [95% CI, 1.48-4.61]; men: adjusted HR, 3.36 [95% CI, 2.01-5.60]). When stratifying by age, female sex was associated with a lower risk of fatal or nonfatal myocardial infarction in those aged <60 years; however, among older individuals, the risk conferred by elevated lipoprotein(a) was similar between men and women. CONCLUSIONS: Among individuals with no prior atherosclerotic cardiovascular disease, elevated lipoprotein(a) is associated with higher rates of cardiovascular outcomes, particularly myocardial infarction, in both women and men.
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Kaur et al. (2025) studied this question.
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