Why the study?
The weight-adjusted waist index represents a novel indicator of central obesity, but its association with coronary heart disease required investigation.
Is a higher weight-adjusted waist index (WWI) associated with an increased risk of coronary heart disease?
Is a higher weight-adjusted waist index (WWI) associated with an increased risk of coronary heart disease?
The weight-adjusted waist index (WWI), a novel indicator for central obesity, is associated with an increased risk of coronary heart disease and may serve as an independent risk factor.
May support WWI as CHD risk marker in cross-sectional data; leaves open prospective validation and incremental utility.
Background: The weight adjusted waist index (WWI) represents a novel indicator for assessing central obesity. The objective of this study is to investigate the association between WWI and coronary heart disease (CHD). Method: The data of 44,528 participants in total were gathered from NHANES database from 1999 to 2020. WWI is calculated as the waist circumference (WC, cm) divided by the square root of the body weight (kg), and CHD was determined based on participants' self-reports. The association between WWI and CHD was examined using multiple logistic regression analysis, restrictive cubic spline (RCS), receiver operating characteristic (ROC) curve, mediation analysis, subgroup and interaction analyses. Result: for interaction <0.05). Conclusion: The level of WWI has been demonstrated to be associated with an increased risk of CHD. Specifically, as WWI increases, the risk of CHD becomes higher. On this basis, it is hypothesized that WWI may potentially serve as an independent risk factor for CAD, thereby highlighting the substantial value of WWI in the identification and management of CHD.
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Liu et al. (2025) studied this question.
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