Periaortic Fat Deposition Is Associated With Peripheral Arterial Disease
Why the study?
Is periaortic fat deposition associated with clinical peripheral arterial disease and low ankle-brachial index?
Population
1205 participants from the Framingham Heart Study Offspring cohort (mean age 65.9 years, 54% women)
Design
Cohort
Authors
Discussion
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Member takes
Implication
Periaortic fat may identify higher PAD risk beyond BMI or visceral adiposity; extends ectopic fat research but remains hypothesis-generating.
Structured PICO
Is periaortic fat deposition associated with clinical peripheral arterial disease and low ankle-brachial index?
P
Population
1205 participants from the Framingham Heart Study Offspring cohort (mean age 65.9 years, 54% women)
I
Intervention
Periaortic fat surrounding the thoracic aorta quantified using a volumetric approach
O
Outcome
Combined end point of intermittent claudication or low ankle-brachial index (≤ 0.9) or lower-extremity revascularizationcomposite
Periaortic fat deposition is independently associated with peripheral arterial disease, suggesting a localized pathogenic role of ectopic fat depots on vascular disease.
Cite This Study
Fox et al. (2010) studied this question.