June 13, 2011Circulation
Mitral Valve Abnormalities Identified by Cardiovascular Magnetic Resonance Represent a Primary Phenotypic Expression of Hypertrophic Cardiomyopathy
Why the study?
Are mitral valve leaflets elongated in patients with hypertrophic cardiomyopathy compared to controls as assessed by cardiovascular magnetic resonance?
Population
172 patients with hypertrophic cardiomyopathy, 172 control subjects, and 15 HCM…
Comparison
Cine cardiovascular magnetic resonance imaging vs Control subjects
Design
Case-control
Authors
Discussion
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Member takes
Implication
Mitral leaflet elongation associated with HCM on CMR independent of hypertrophy; supports primary phenotype but hypothesis-generating.
Structured PICO
Are mitral valve leaflets elongated in patients with hypertrophic cardiomyopathy compared to controls as assessed by cardiovascular magnetic resonance?
P
Population
172 patients with hypertrophic cardiomyopathy (HCM) (mean age 42±18 years, 62% men), 172 control subjects, and 15 HCM gene-positive/phenotype-negative relatives.
I
Intervention
Cine cardiovascular magnetic resonance (CMR) imaging
C
Comparator
Control subjects
O
Outcome
Anterior mitral leaflet (AML) and posterior mitral leaflet lengthssurrogate
Mitral valve leaflets are elongated in HCM patients independently of LV hypertrophy, suggesting it is a primary phenotypic expression of the disease identifiable by CMR.
Cite This Study
Maron et al. (2011) studied this question.