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January 1, 2016Journal of Cardiovascular Magnetic ResonanceOpen Access

Cardiovascular magnetic resonance of mitral valve length in hypertrophic cardiomyopathy

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Why the study?

Does cardiovascular magnetic resonance reveal mitral valve leaflet elongation as a primary phenotypic expression in patients with hypertrophic cardiomyopathy?

Population

218 subjects, including 47 with the MYBPC3-Q1061X mutation, 20 healthy relatives without the mutation, 80…

Comparison

Cardiovascular magnetic resonance measurement of… vs Healthy controls

Design

Cross-sectional

Authors

MTMika TarkiainenKuopio University HospitalPSPetri SipolaKuopio University HospitalMJMikko JalankoHelsinki University Hospital

Discussion

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Implication

Mitral leaflet length in MYBPC3 carriers may mark preclinical HCM; leaves open whether elongation precedes hypertrophy or alters management.

Structured PICO

Does cardiovascular magnetic resonance reveal mitral valve leaflet elongation as a primary phenotypic expression in patients with hypertrophic cardiomyopathy?

P
Population
218 subjects, including 47 with the MYBPC3-Q1061X mutation (32 with left ventricular hypertrophy [LV maximal wall thickness ≥ 13 mm], 15 without LVH), 20 healthy relatives without the mutation, 80 consecutive non-genotyped patients with HCM, and 71 age- and gender-matched healthy subjects.
I
Intervention
Cardiovascular magnetic resonance (CMR) measurement of mitral valve leaflet lengths
C
Comparator
Healthy controls (relatives without the mutation and age/gender-matched healthy subjects)
O
Outcome
Anterior mitral valve leaflet (AML) and posterior mitral valve leaflet (PML) lengthssurrogate

Mitral valve elongation in hypertrophic cardiomyopathy appears to be associated with body size and left ventricular remodeling rather than being a primary phenotypic expression of the disease.

Cite This Study

Tarkiainen et al. (2016) studied this question.

synapsesocial.com/papers/6a7022fbabc331a858079574https://doi.org/10.1186/s12968-016-0250-5

Topics

Hypertrophic cardiomyopathy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abnormal septal convexity into the left ventricle occurs in subclinical hypertrophic cardiomyopathy2015 · 34 citations
  2. 2Cine MR Imaging of Myocardial Contractile Impairment in Patients with Hypertrophic Cardiomyopathy Attributable to Asp175Asn Mutation in the α-Tropomyosin Gene2005 · 32 citations
  3. 3Two founder mutations in the alpha-tropomyosin and the cardiac myosin-binding protein C genes are common causes of hypertrophic cardiomyopathy in the Finnish population2012 · 46 citations
  4. 4Sarcomere Protein Gene Mutations in Hypertrophic Cardiomyopathy of the Elderly2002 · 365 citations
  5. 5Structural Characterization of the C3 Domain of Cardiac Myosin Binding Protein C and Its Hypertrophic Cardiomyopathy-Related R502W Mutant2014 · 25 citations