July 20, 2004Circulation

Cardiac Memory Evolves With Age in Association With Development of the Transient Outward Current

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Structured PICO

Population

Acutely anesthetized dogs from 1 day old to adult (n=41 for pacing protocol, plus 20 additional dogs for microelectrode studies)

Intervention

Cardiac pacing from the left ventricle (VP) to induce cardiac memory

Comparator

Cardiac pacing from the left atrial appendage (AP) and comparison across different age groups

Outcome

T-wave vector displacement (TVD), epicardial action potential notch magnitude, and mRNA expression for KChIP2 and Kv4.3surrogate

The inducibility of cardiac memory increases with age, which is associated with the developmental maturation of the transient outward current (I(to)) and its molecular determinants.

Discussion

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Implication

Age effects on cardiac memory in this animal model should not yet change pediatric pacing; leaves open translational role of I(to) maturation.

Cite This Study

Plotnikov et al. (2004) studied this question.

synapsesocial.com/papers/69f3ee85dc238f819779983a https://doi.org/10.1161/01.cir.0000137823.64947.52

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Implication

Age effects on cardiac memory in this animal model should not yet change pediatric pacing; leaves open translational role of I(to) maturation.

Cardiac Memory Evolves With Age in Association With Development of the Transient Outward Current

Structured PICO

Discussion

Implication

Cite This Study

Cardiac Memory Evolves With Age in Association With Development of the Transient Outward Current

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider