April 13, 1999CirculationOpen Access

Transient Outward Current, I to1 , Is Altered in Cardiac Memory

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Population

Conscious dogs

Comparison

Ventricular pacing at 120 bpm for 3 weeks to… vs Control dogs/myocytes

Design

Preclinical

Follow-up

3 weeks

Authors

HYHan‐Gang YuWest Virginia University DMDavid McKinnonState University of New York JDJane E. DixonState University of New York

Discussion

Member takes

Implication

Prolonged Ito recovery in LTM myocytes may underlie T-wave memory; leaves open human translation and clinical relevance.

Structured PICO

Population

Conscious dogs

Intervention

Ventricular pacing at 120 bpm for 3 weeks to induce long-term cardiac memory (LTM)

Comparator

Control dogs/myocytes

Outcome

Changes in transient outward current (Ito) and action potential characteristics in left ventricular epicardial myocytessurrogate

Long-term cardiac memory induced by ventricular pacing is associated with alterations in the transient outward current (Ito), providing a mechanistic explanation for the observed action potential and T-wave changes.

Cite This Study

Yu et al. (1999) studied this question.

synapsesocial.com/papers/6a10d8a4acd1dbe064648006 https://doi.org/10.1161/01.cir.99.14.1898

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Transient Outward Current, I to1 , Is Altered in Cardiac Memory

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Transient Outward Current, I to1 , Is Altered in Cardiac Memory

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider