Key result
In canine Purkinje myocytes surviving 48 hours post-infarction, Ito1 current density was significantly reduced compared to normal cells (9 vs 20.2 pA/pF, P<0.01).
Absolute Event Rate: 9% vs 20.2%
p-value: p=< .01
In subendocardial Purkinje myocytes surviving 48 hours post-infarction, the density of transient outward currents (Ito1) is markedly reduced with altered kinetics, potentially contributing to arrhythmogenesis.
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Hypothesis-generating for Ito1 in post-MI arrhythmogenesis; no clinical implications from this animal study.
Jeck et al. (1995) studied Myocardial infarction (canine model) (n=43). 48-hour myocardial infarction vs. Normal canine heart Purkinje myocytes was evaluated on Ito1 current density (p=< .01). In canine Purkinje myocytes surviving 48 hours post-infarction, Ito1 current density was significantly reduced compared to normal cells (9 vs 20.2 pA/pF, P<0.01).
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