Key result
In a canine model of ischemic cardiomyopathy, myocytes exhibited prolonged action potential duration and reduced slow delayed rectifier, transient outward, and inward rectifier currents.
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No immediate clinical implications from canine model; leaves open whether these ion current changes drive human ischemic cardiomyopathy arrhythmias.
Liu et al. (2006) studied Ischemic cardiomyopathy. Ischemic cardiomyopathy (induced by microembolizations) vs. Normal hearts was evaluated on Action potential duration and ionic currents. In a canine model of ischemic cardiomyopathy, myocytes exhibited prolonged action potential duration and reduced slow delayed rectifier, transient outward, and inward rectifier currents.
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