March 1, 1998Journal of Cardiovascular Electrophysiology

Reduced Inward Rectifying and Increased E‐4031‐Sensitive K+ Current Density in Arrhythmogenic Subendocardial Purkinje Myocytes from the Infarcted Heart

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Population

Subendocardial Purkinje myocytes from the 48-hour infarcted heart (IZPCs) and normal Purkinje myocytes (NZPCs)

Comparison

Whole cell patch recordings with E-4031 vs Normal Purkinje myocytes (NZPCs)

Design

Preclinical

Authors

JPJudith M.B. PintoNew Hope Fertility Center PBPenelope A. BoydenElectrophysiology

Discussion

Member takes

Implication

May inform Purkinje cell contributions to post-MI arrhythmias; leaves open translation to human ventricular tachycardia.

Structured PICO

Population

Subendocardial Purkinje myocytes from the 48-hour infarcted heart (IZPCs) and normal Purkinje myocytes (NZPCs)

Intervention

Whole cell patch recordings with E-4031 (Class III antiarrhythmic agent)

Comparator

Normal Purkinje myocytes (NZPCs)

Outcome

Cesium-sensitive IK1 and 4-aminopyridine (4-AP)-resistant, noninactivating sustained IK (E-4031-sensitive currents)surrogate

Decreased IK1 may account for reduced resting potentials in infarcted Purkinje myocytes, and E-4031-sensitive currents are larger in these cells, providing insights into post-infarction arrhythmogenesis.

Cite This Study

Pinto et al. (1998) studied this question.

synapsesocial.com/papers/6a6fbd72b27f15817827143a https://doi.org/10.1111/j.1540-8167.1998.tb00915.x

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Reduced Inward Rectifying and Increased E‐4031‐Sensitive K+ Current Density in Arrhythmogenic Subendocardial Purkinje Myocytes from the Infarcted Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Reduced Inward Rectifying and Increased E‐4031‐Sensitive K+ Current Density in Arrhythmogenic Subendocardial Purkinje Myocytes from the Infarcted Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider