Role of L-Type Calcium Channels in Pacing-Induced Short-Term and Long-Term Cardiac Memory in Canine Heart
Why the study?
Does L-type calcium channel blockade prevent pacing-induced short-term and long-term cardiac memory in a canine model?
Structured PICO
Does L-type calcium channel blockade prevent pacing-induced short-term and long-term cardiac memory in a canine model?
P
Population
Canine heart model (acutely anesthetized and chronically instrumented conscious dogs, isolated epicardial and endocardial slabs, left ventricular epicardial myocytes)
I
Intervention
L-type Ca2+ channel blockade (nifedipine for short-term memory, amlodipine for long-term memory), beta-blockade (propranolol for short-term memory, atenolol for long-term memory), AT1 receptor blockade (candesartan for long-term memory), and ACE inhibition (trandolapril for long-term memory)
C
Comparator
Placebo or sham control
O
Outcome
Evolution of short-term memory (STM) and long-term memory (LTM)surrogate
L-type calcium channel blockade, but not beta-adrenergic or angiotensin II blockade, suppresses pacing-induced cardiac memory in dogs, which is associated with altered calcium channel kinetics.
Authors
Discussion
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Implication
L-type Ca channel blockade attenuates cardiac memory in dogs; leaves open clinical translation and human relevance.
Cite This Study
Plotnikov et al. (2003) studied this question.