Key result
Infusion of renin-angiotensin system blockers (saralasin, captopril, or chymostatin) significantly reduced the incidence and accumulation of pacing-induced cardiac memory in dogs.
Why the study?
Does blockade of the renin-angiotensin system reduce the incidence and accumulation of cardiac memory induced by ventricular pacing in dogs?
Population
Anesthetized dogs (n=21) and isolated, blood-perfused canine hearts (n=4)
Comparison
Infusion of saralasin, captopril, or chymostatin… vs Control dogs undergoing ventricular pacing…
Design
Preclinical
Authors
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RAS inhibition attenuates cardiac memory accumulation in paced dogs; leaves open any clinical relevance or human translation.
Does blockade of the renin-angiotensin system reduce the incidence and accumulation of cardiac memory induced by ventricular pacing in dogs?
p-value: p=<0.05
Blockade of the endogenous cardiac renin-angiotensin II system significantly reduces the induction of cardiac memory following ventricular pacing in a canine model.
Ricard et al. (1999) studied Cardiac memory (n=25). Renin-angiotensin system blockers (saralasin, captopril, chymostatin) vs. Control was evaluated on Change (delta) in T wave vector angle showing accumulation over three monitoring periods (p=<0.05). Infusion of renin-angiotensin system blockers (saralasin, captopril, or chymostatin) significantly reduced the incidence and accumulation of pacing-induced cardiac memory in dogs.
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