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March 1, 2001Clinical ChemistryOpen Access

Variability and Classification Accuracy of Serial High-Sensitivity C-Reactive Protein Measurements in Healthy Adults

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Why the study?

Does hs-CRP have comparable measurement stability and classification accuracy to total serum cholesterol in healthy adults?

Population

113 healthy adults

Design

Cohort

Follow-up

1 year

Authors

IOIra S. OckeneWorcester Polytechnic InstituteCMCharles E. MatthewsORCID
Nader Rifai
Nader RifaiPreventive Cardiology

Discussion

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Implication

hs-CRP stability matches cholesterol for risk stratification; supports reliability but leaves open outcome impact in cohorts.

Structured PICO

Does hs-CRP have comparable measurement stability and classification accuracy to total serum cholesterol in healthy adults?

P
Population
113 healthy adults
I
Intervention
Five measurements each of hs-CRP and total cholesterol carried out at quarterly intervals over a 1-year period
O
Outcome
Variations of hs-CRP and total cholesterol, and classification accuracysurrogate

hs-CRP demonstrates measurement stability comparable to total cholesterol, supporting its reliability for cardiovascular risk assessment.

Cite This Study

Ockene et al. (2001) studied this question.

synapsesocial.com/papers/69f41cfcf3e494ed2b7d0368https://doi.org/10.1093/clinchem/47.3.444
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