December 15, 1992Annals of Internal Medicine
Prognostic Implications of Asymptomatic Ventricular Arrhythmias: The Framingham Heart Study
Why the study?
Does the presence of asymptomatic complex or frequent ventricular arrhythmias predict all-cause mortality and myocardial infarction or death from coronary heart disease in a population-based cohort?
Population
6,033 surviving patients of the original Framingham Heart Study cohort and offspring
Comparison
Asymptomatic complex or frequent ventricular… vs Absence of complex or frequent ventricular…
Design
Cohort
Follow-up
4 to 6 years
Authors
Discussion
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Member takes
Implication
May warrant closer monitoring in asymptomatic men; leaves open whether arrhythmia suppression improves outcomes.
Structured PICO
Does the presence of asymptomatic complex or frequent ventricular arrhythmias predict all-cause mortality and myocardial infarction or death from coronary heart disease in a population-based cohort?
P
Population
6,033 surviving patients of the original Framingham Heart Study cohort and offspring (2,727 men and 3,306 women)
I
Intervention
Asymptomatic complex or frequent ventricular premature beats (>30 ventricular premature complexes per hour or multiform premature complexes, ventricular couplets, ventricular tachycardia, or R-on-T ventricular premature complexes) detected during 1-hour ambulatory ECG monitoring
C
Comparator
Absence of complex or frequent ventricular arrhythmias
O
Outcome
All-cause mortality and the occurrence of myocardial infarction or death from coronary heart diseasehard clinical
Incidental detection of asymptomatic complex or frequent ventricular arrhythmias on ambulatory ECG is associated with a twofold increase in risk for all-cause mortality and coronary events in men without clinically apparent coronary heart disease.
Cite This Study
Bikkina et al. (1992) studied this question.