Comparative Pharmacokinetics and Bioequivalence Assessment of Metformin/Pioglitazone Tablet in Fasting and Fed Conditions: A Randomized Study in Healthy Chinese Subjects.

Key Points

• This research aims to evaluate the bioequivalence and pharmacokinetics of metformin/pioglitazone tablets in different physiological states.
• Conducted as a randomized trial in healthy Chinese subjects under fasting and fed conditions.
• Compared pharmacokinetic parameters of tested and reference formulations.
• Measured bioequivalence limits within acceptable ranges.
• Both formulations were bioequivalent within accepted limits (0.80-1.25).
• No serious adverse events were recorded during the trial.