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May 1, 2026

An Epidemiological Study on the Relationship between Gastric Mucosal Atrophy, Exhaled Hydrogen Concentration, and Gut Microbiota.

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Epidemiological investigation reveals link between gastric mucosal atrophy and exhaled hydrogen in residents, suggesting microbiota alterations.

Investigate the relationship between gastric mucosal atrophy, exhaled hydrogen concentration, and gut microbiota.
Divided participants into control (n=903) and atrophy (n=63) groups using specific cut-off values.
Compared exhaled hydrogen gas concentrations and gut microbiota in selected participants using propensity score matching.
Categorized participants based on H. pylori infection statuses: non-infection, persistent infection, or post-eradication.
66.0% of the atrophy group were persistent H. pylori carriers; 39.6% of the control group had undergone eradication.
Atrophy group showed lower exhaled hydrogen concentrations compared to the control group.
Alterations in gut microbiota were observed in the atrophy group with increased Streptococcus and decreased Blautia.

Sato et al. (2026) studied this question.

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Epidemiological investigation reveals link between gastric mucosal atrophy and exhaled hydrogen in residents, suggesting microbiota alterations.