What does this research mean for the field?

Patients with gastric mucosal atrophy and reduced gastric acid production experience a lower frequency of gastroesophageal reflux disease symptoms compared to individuals with normal acid production. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the prevalence of gastroesophageal reflux disease symptoms in relation to the presence of gastric mucosal atrophy.

August 23, 2026Diseases of the Esophagus

P1.032. Frequency of Gastroesophageal Reflux Disease in Patients Depending on the Presence of Gastric Mucosal Atrophy

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Authors

KNKarine NikolskayaMoscow Clinical Scientific Center MCMargarita ChebotarevaMoscow Clinical Scientific Center DBDmitri BordinMoscow Clinical Scientific Center

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Implication

Epidemiological study reveals lower rates of gastroesophageal reflux symptoms in individuals with gastric mucosal atrophy, indicating that reduced acid production decreases symptom frequency.

Key Points

To evaluate the prevalence of gastroesophageal reflux disease symptoms in relation to the presence of gastric mucosal atrophy.
Epidemiological evaluation of N=4436 individuals (aged 18–84 years) utilizing serum GastroPanel blood testing.
Classified gastric mucosal atrophy as Pepsinogen I ≤ 30 μg/L with a Pepsinogen I/Pepsinogen II ratio ≤ 3, and defined GERD as heartburn or regurgitation occurring at least once per week.
Gastric mucosal atrophy with reduced serum pepsinogen levels was present in 6.2% (292/4436) of participants.
GERD symptoms occurred in 9.6% (28 of 292) of respondents with reduced pepsinogen levels compared to 19.0% (844 of 4436) of respondents with normal pepsinogen levels.

Cite This Study

Nikolskaya et al. (2026) studied this question.

synapsesocial.com/papers/6a8aadf37677a341144467f6 https://doi.org/10.1093/dote/doag077.180

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Implication

Epidemiological study reveals lower rates of gastroesophageal reflux symptoms in individuals with gastric mucosal atrophy, indicating that reduced acid production decreases symptom frequency.

P1.032. Frequency of Gastroesophageal Reflux Disease in Patients Depending on the Presence of Gastric Mucosal Atrophy

Discussion

Member takes

Implication

Key Points

Cite This Study

P1.032. Frequency of Gastroesophageal Reflux Disease in Patients Depending on the Presence of Gastric Mucosal Atrophy

Discussion

Member takes

Implication

Key Points

Cite This Study

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