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September 20, 2025Diseases of the Esophagus

Yield of upper endoscopy and predictors of clinically relevant outcomes in patients with proton pump inhibitor–refractory heartburn

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Authors

FBFadi Abu Baker RHRawi Hazzan OGO. Gal

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Overview

Retrospective cohort study assesses diagnostic yield of gastroscopy and predictors of clinically significant findings in GERD patients, revealing low prevalence of upper GI malignancies.

Key Points

Gastroscopy identified clinically significant findings in 11.5% of patients with PPI-refractory heartburn, indicating modest diagnostic yield.
Statistically significant differences in CSF detection were found, with 27.9% in untreated patients, 18.2% in H2RA users, and 11.5% in PPI users.
Multivariate logistic regression highlighted older age, hiatal hernia, and shorter PPI duration as independent predictors of clinically significant findings.
The prevalence of upper GI malignancies was low across age groups, emphasizing a need for optimized therapy and lifestyle adjustments before endoscopy.

Cite This Study

Baker et al. (2025) studied this question.

synapsesocial.com/papers/68d46fc631b076d99fa69a8e https://doi.org/10.1093/dote/doaf072

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September 20, 2025Diseases of the Esophagus

Yield of upper endoscopy and predictors of clinically relevant outcomes in patients with proton pump inhibitor–refractory heartburn

View Full Paper

Ask AI

Bookmark

Authors

FBFadi Abu Baker RHRawi Hazzan OGO. Gal

Discussion

Member takes

Overview

Retrospective cohort study assesses diagnostic yield of gastroscopy and predictors of clinically significant findings in GERD patients, revealing low prevalence of upper GI malignancies.

Key Points

Gastroscopy identified clinically significant findings in 11.5% of patients with PPI-refractory heartburn, indicating modest diagnostic yield.
Statistically significant differences in CSF detection were found, with 27.9% in untreated patients, 18.2% in H2RA users, and 11.5% in PPI users.
Multivariate logistic regression highlighted older age, hiatal hernia, and shorter PPI duration as independent predictors of clinically significant findings.
The prevalence of upper GI malignancies was low across age groups, emphasizing a need for optimized therapy and lifestyle adjustments before endoscopy.

Cite This Study

Baker et al. (2025) studied this question.

synapsesocial.com/papers/68d46fc631b076d99fa69a8e https://doi.org/10.1093/dote/doaf072

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