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Synapse
May 1, 2026

Gonadotrope Remodeling in Sustained Low Estrogen States: Single-Cell Transcriptomic Analysis Reveals Gonadotrope Subtypes and Activation of Stem Cell Populations.

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Authors

AOAngela K. OdleTMTiffany K. MilesAHAshley Herdman

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Overview

Randomized trial investigates the effects of low estrogen on pituitary function, suggesting insights into menopausal physiology.

Key Points

  • This research aims to explore how low estrogen levels impact gonadotrope function and stem cell activation in the pituitary gland.
  • Used a VCD-induced ovarian failure model to decrease estrogen levels gradually.
  • Conducted single-cell RNA sequencing to analyze gene expression in gonadotropes.
  • Identified two distinct gonadotrope populations based on gene expression signatures.
  • GON1 population significantly increased in low estrogen conditions, expressing stem cell activation markers.
  • Gonadotropins FSH and LH levels rose 8-15-fold, correlating with increased Fshb and Lhb mRNA levels.
  • Sox2-positive stem cells showed enhanced expression of transitional progenitors, indicating stem cell activity.

Cite This Study

Odle et al. (2026) studied this question.

synapsesocial.com/papers/69f442d4967e944ac55663a2https://doi.org/10.1093/biolre/ioag091
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