Demonstrates improved healing in diabetic wounds using a novel ROS-modulating hydrogel, indicating effective infection management.
in diabetic wounds to generate ROS through their remarkable peroxidase (POD)-like activity under near-infrared (NIR) irradiation. Coupled with NIR enhanced glutathione (GSH) depletion ability, the rapid elimination of multiple pathogens and biofilms during the early stage of wound healing were enhanced. Besides, released LEVs promote macrophage to M2 phenotype polarization by restoring mitochondrial function, reducing intracellular ROS levels, and suppressing NF-κB activation, thereby alleviating the pro-inflammatory microenvironment and promoting diabetic wound healing. This integrated nanozyme-LEVs system synergistically addresses infection and immune dysregulation through adaptive ROS modulation, offering a precise and intelligent strategy for diabetic wound management.
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Zhang et al. (2026) studied this question.
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