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Transcriptomic meta‐analysis identifies core molecular pathways in plaque psoriasis

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Meta-analysis integrates immune-gene expression patterns in plaque psoriasis, suggesting new research pathways.

This study aims to define consistent immune-gene expression patterns in plaque psoriasis through transcriptomic integration.
Conducted a systematic review and meta-analysis of 44 studies with 975 samples.
Compared lesional psoriatic skin to non-lesional skin and healthy controls using random-effects models.
Performed functional enrichment analysis with Reactome, KEGG, and GO databases.
Identified 1780 immune-related genes dysregulated in lesional psoriasis.
Confirmed established immune pathways, including IL-23/Th17 signalling.
Highlighted less-characterized processes involving glucose metabolism, FoxO signalling, and mitophagy.

Torres‐Moral et al. (2026) studied this question.

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