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This research aims to clarify the clinicopathologic features of vulvar LSIL and small condyloma to improve diagnostic criteria.

May 1, 2026

Vulvar Low-Grade Squamous Intraepithelial Lesion (LSIL) and Small Condyloma are Overlapping Clinicopathologic Entities.

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Randomized trial describes clinicopathologic similarities of vulvar LSIL and small condyloma, highlighting their diagnostic nuances.

This research aims to clarify the clinicopathologic features of vulvar LSIL and small condyloma to improve diagnostic criteria.
Identified vulvar biopsies from a pathology database, excluding cancer specimens and large condyloma.
Reviewed histopathology and p16 staining to classify cases as LSIL or condyloma.
Conducted descriptive statistics and group comparisons for clinical information.
Out of 42 women, 24 (57%) had condyloma, 13 (31%) had LSIL, 5 (12%) had both.
LSIL was characterized by smooth surface morphology, normal epithelial thickness, and higher p16 positivity compared to condyloma.
Condyloma presented as larger with elongated rete ridges and was more frequently treated than cases designated as LSIL.

Scolyer et al. (2026) studied this question.

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