Why the study?
Does high-dose prednisone therapy improve muscle strength and functional ability in boys with Duchenne muscular dystrophy?
Population
33 boys with Duchenne muscular dystrophy
Comparison
Prednisone 1.5 mg/kg of body weight daily for… vs Natural history controls
Design
Cohort
Follow-up
6 months
Authors
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Supports short-term gains with high-dose prednisone in DMD; leaves open need for randomized confirmation.
Does high-dose prednisone therapy improve muscle strength and functional ability in boys with Duchenne muscular dystrophy?
High-dose prednisone therapy over six months improves muscle strength, functional ability, and pulmonary function in boys with Duchenne muscular dystrophy.
Michael H. Brooke (1987) studied this question.