DQIS — Register of Scientific Objections v4.0

Supplementary document to the DQIS framework (Zenodo DOI: 10.5281/zenodo.19855263). Register of scientific objections identified during preparation for academic validation of the DQIS framework — Distributed Quantum-Inspired Immune Surveillance. Version 4.0 — 12 objections addressed: O1 — Empirical grounding of parameter p_i O2 — Statistical independence of channels (balanced group quorum) O3 — Selective pressure at population scale O4 — Channel T-ε: reachability of p_i = 0.01 O5 — DQIS-J: number of paediatric procedures O6 — T-γ* temporal criterion vs T-cell contact time (NFAT-like integration) O7 — Clonal hematopoietic drift (CHIP) disrupts the 5-pool balance of DQIS-A [NEW] O8 — Progressive epigenetic silencing of transgenes in differentiated T cells [NEW] O9 — Balanced-quorum co-presence probability in the TME not quantified [NEW] O10 — Bulk-derived correlations ρ_ij underestimate single-cell correlations [NEW] O11 — Ci-VSP (Ciona intestinalis) may elicit CTL response against T-γ* cells [NEW] O12 — Sub-threshold dormant cells (CDIC) systematically evade detection [NEW] Not a peer-reviewed publication. Prior art deposit.Contact: dqis.research@proton.meRelated documents: - DQIS Consolidated Framework (main document): https://zenodo.org/records/19877553 - Addendum I — Temporal Stratification of Tail Dependence Risk: https://zenodo.org/records/19877810