DQIS — Register of Scientific Objections v6.0

Supplementary document to the DQIS framework (Zenodo DOI: 10.5281/zenodo.19855263). Register of scientific objections identified during preparation for academic validation of the DQIS framework — Distributed Quantum-Inspired Immune Surveillance. Version 6.0 (April 2026) — 12 objections addressed: O1 — Empirical grounding of parameter p_i O2 — Statistical independence of channels — updated v6.0: empirically validated on GSE72056 (1,257 malignant melanoma cells); inter-group M/E pairs show LTD ≈ 0, θ ≈ 0.17; intra-M vulnerability (T-α/T-β, θ=0.905) confirmed and resolved by balanced quorum O3 — Selective pressure at population scale O4 — Channel T-ε: reachability of p_i = 0.01 O5 — DQIS-J: number of paediatric procedures O6 — T-γ* temporal criterion vs T-cell contact time (NFAT-like integration) O7 — Clonal hematopoietic drift (CHIP) disrupts the 5-pool balance of DQIS-A O8 — Progressive epigenetic silencing of transgenes in differentiated T cells O9 — Balanced-quorum co-presence probability in the TME — resolved v5.0: Monte Carlo quantification + Double Memory Imprint (P_quorum from 2.5% to ~85% in hot tumors) O10 — Bulk-derived correlations ρ_ij underestimate single-cell correlations — resolved v6.0: empirical analysis on real single-cell data (GSE72056) O11 — Ci-VSP (Ciona intestinalis) may elicit CTL response against T-γ* cells — resolved v6.0: in silico anchor-based prediction (HLA-A*02:01 PWM); no strong binders on cytoplasmic peptides; PTEN cross-reactivity signal identified (FVLTPSSHV, 8/9 aa identity); H→Q mutation at P8 recommended before Phase 1; no impact on Phase 0 PoC O12 — Sub-threshold dormant cells (CDIC) systematically evade detection Not a peer-reviewed publication. Prior art deposit.Contact: dqis.research@proton.meRelated documents: - DQIS Consolidated Framework (main document): https://zenodo.org/records/19877553 - Addendum I — Temporal Stratification of Tail Dependence Risk: https://zenodo.org/records/19877810