Incident Hypertension in Young Adults With a Mild Estimated Glomerular Filtration Rate Reduction.

Figures

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  Figure 1. Crude rates (events per 1000 person‐years) and adjusted HRs (adjusted for sex, hypertension, diabetes, past cardiovascular disease, hypercholesterolemia, hyperkalemia, cancer, chronic liver disease, chronic lung disease, income quintile, urban or rural living status, specialist visit in the past 5 years, and emergency department visit in the past 5 years) (95% CI) for incident hypertension, relative to age‐specific eGFR reference ranges, by age group. eGFR indicates estimated glomerular filtration rate; HR, hazard ratio; and ref, referent.

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  Figure 2. Adjusted (adjusted for sex, hypertension, diabetes, past cardiovascular disease, hypercholesterolemia, hyperkalemia, cancer, chronic liver disease, chronic lung disease, income quintile, urban or rural living status, specialist visit in the past 5 years, and emergency department visit in the past 5 years) HRs (95% CI) of incident hypertension by interacting categories of index eGFR (mL/min per 1.73 m2) and ACR (mg/mmol), stratified by age group (reference: age‐specific reference category (reference categories by age: eGFR 100 to <110 mL/min per 1.73 m2 for 18–39 years, 90 to <100 mL/min per 1.73 m2 for 40–49 years, and 80 to <90 mL/min per 1.73 m2 for 50–65 years) and <3 mg/mmol (estimates that are not statistically significant are shown in italics). HR ≤1.25 (green): minimal or no risk; HR 1.26 to 1.50 (light green): low risk; HR 1.51 to 2.00 (yellow): elevated risk; HR 2.01 to 2.99 (orange): moderate risk; HR ≥3.00: high risk. ACR indicates albumin/creatinine ratio; eGFR, estimated glomerular filtration rate; and HR, hazard ratio.