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May 1, 2026Open Access

Rp HPLC Method for Simultaneous Estimation of Metformin and Sitagliptin

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Authors

UVUppunoothula Kalyan*1, Samba Praveen Kumar2, Samrin Saddam3, Priyanka Raj3, Rohit Kori3, Dr. Sepuri Vijayalaxmi4

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Overview

Randomized trial estimates purity and precision for Metformin and Sitagliptin using RP-HPLC.

Key Points

  • The aim is to establish an RP-HPLC method for accurately estimating Metformin and Sitagliptin concentrations.
  • Developed chromatographic conditions using a Thermosil C18 column for separation.
  • Validated according to ICH guidelines with a focus on linearity, precision, and recovery.
  • Conducted linearity study over specified concentration ranges for both drugs.
  • Metformin and Sitagliptin presented % purity of 101.03% and 99.27%, respectively.
  • The correlation coefficient (r2) for both drugs was found to be 0.999.
  • LOD of Metformin was 3.17 and for Sitagliptin was 0.0172.

Cite This Study

Uppunoothula Kalyan*1, Samba Praveen Kumar2, Samrin Saddam3, Priyanka Raj3, Rohit Kori3, Dr. Sepuri Vijayalaxmi4 (2026) studied this question.

synapsesocial.com/papers/69f44488967e944ac556788dhttps://doi.org/10.5281/zenodo.19883343
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